neuropeptide y การใช้

• Neuropeptide y is believed to play a major role in stimulating appetite.
• Normally when animals fast, neuropeptide Y sharply jumps and appetite consequently increases.
• When scientists injected C75-treated mice with neuropeptide Y, they immediately stuffed themselves.
• The neuropeptide Y neurons also make the classical inhibitory neurotransmitter GABA.
• These include interneurons that express tyrosine hydroxylase and neuropeptide Y.
• For example, neuropeptide Y, NPY, is the most powerful stimulant of feeding known, Bloom said.
• When neuropeptide Y was injected into animals, it made even full animals eat more, researchers found.
• High levels of the molecule somehow signaled the brain not to produce neuropeptide Y, Kuhajda said.
• When injected into the hypothalamus of a rat, neuropeptide Y has been shown to induce overeating immediately.
• Interneurons are also divided into subgroups by the expression of neuropeptides such as somatostatin, neuropeptide Y, cholecystokinin.
• Another company, Neurogen Corp ., is working with Pfizer Inc . on a drug that blocks neuropeptide y.
• For more than a decade, scientists have known that a brain chemical called NPY, for neuropeptide Y, stimulates appetite.
• Neurogen is also testing a drug that would treat depression through acting on Neuropeptide Y, which helps regulate norepinephrine.
• -Neurons that express hypothalamic neuropeptide Y and agouti gene-related protein or pro-opiomelanocortin and that originate in the arcuate nucleus.
• It turns out that production of a brain chemical called neuropeptide Y-- a well-known appetite regulator-- plummeted in the C75-treated mice.
• Butyrate binding at FFAR3 induces neuropeptide Y release and promotes the functional homeostasis of colonic mucosa and the enteric immune system.
• The drug works by inhibiting a transmitter in the brain, known as neuropeptide Y, which researchers believe makes people feel hungry.
• Inputs from neuropeptide Y-containing neurons in the arcuate nucleus coordinate metabolic regulation ( via TRH secretion ) with regulation of energy intake.
• Neuropeptide Y has been reported to reduce the release of norepinephrine and has been demonstrated to have anxiolytic properties in animal models.
• Leptin receptor activation inhibits neuropeptide Y ( NPY ) and agouti-related peptide ( AgRP ), and activates ?-melanocyte-stimulating hormone ( ?-MSH ).